ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

Base Information

Chemical Name:ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate
CAS No.:1374342-01-4
Molecular Formula:C₂HF₃O₂*C₂₉H₂₆ClF₃N₄O₃
Molecular Weight:685.023
Hs Code.:

ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

Synonyms:ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

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Chemical Property of ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

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Technology Process of ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

There total 8 articles about ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374342-02-5
C₃₄H₃₄ClF₃N₄O₅

: 76-05-1
trifluoroacetic acid

: 1374342-01-4
ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

Guidance literature:: In dichloromethane; for 0.333333h;

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 1374342-01-4
ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / acetonitrile / 0.83 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 3 h / 70 °C / Inert atmosphere

3: benzyltrimethylazanium tetrachloro-λ³-iodanuide / dichloromethane / 24 h / 20 °C

4: pyridine / dichloromethane / 0.42 h / 0 - 20 °C

5: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 48 h / 80 °C / Inert atmosphere

6: hydrogen; palladium 10% on activated carbon / ethyl acetate; ethanol / 1.5 h / Inert atmosphere

7: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 60 °C

8: dichloromethane / 0.33 h

With pyridine; bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzyltrimethylazanium tetrachloro-λ³-iodanuide; triethylamine; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1128268-02-9
ethyl 1-[6-(2-hydroxylphenyl)pyridine-2-yl]-5-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1374342-01-4
ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: benzyltrimethylazanium tetrachloro-λ³-iodanuide / dichloromethane / 24 h / 20 °C

2: pyridine / dichloromethane / 0.42 h / 0 - 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 48 h / 80 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon / ethyl acetate; ethanol / 1.5 h / Inert atmosphere

5: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 60 °C

6: dichloromethane / 0.33 h

With pyridine; bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzyltrimethylazanium tetrachloro-λ³-iodanuide; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;