1H-Indazole-4-carbonitrile

Base Information

• Chemical Name: 1H-Indazole-4-carbonitrile
• CAS No.: 861340-10-5
• Molecular Formula: C8H5N3
• Molecular Weight: 143.148
• Hs Code.: 2933990090
• Mol file: 861340-10-5.mol

Synonyms:4-Indazolenitrile(2CI);

Chemical Property of 1H-Indazole-4-carbonitrile

Chemical Property:

• Vapor Pressure: 1.12E-05mmHg at 25°C
• Melting Point: 157-160 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.684
• Boiling Point: 370.3 °C at 760 mmHg
• PKA: 11.61±0.40(Predicted)
• Flash Point: 126.7 °C
• PSA: 52.47000
• Density: 1.33 g/cm³
• LogP: 1.43458
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-Indazole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-4-carbonitrile

There total 3 articles about 1H-Indazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.5%

zinc cyanide + 4-bromoindazole (186407-74-9) → 1H-indazole-4-carbonitrile (861340-10-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

dicyanozinc (557-21-1) + 4-bromoindazole (186407-74-9) → 1H-indazole-4-carbonitrile (861340-10-5)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 85 ℃;

Reference yield:

zinc(II) cyanide (557-21-1) + 4-bromoindazole (186407-74-9) → 1H-indazole-4-carbonitrile (861340-10-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 85 ℃; for 17h;

upstream raw materials:

dicyanozinc

4-bromoindazole

zinc(II) cyanide

Downstream raw materials:

2-methyl-2H-indazole 4-carbonitrile

3-iodo-1H-indazole-4-carbonitrile

{3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]-3-oxetanyl}acetic acid

5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

Refernces

• 1、 -. "SERINE/THREONINE PAK1 INHIBITORS". Page/Page column 111. . Retrieved 2013/03/26.