(Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

Base Information

Chemical Name:(Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide
CAS No.:1383852-28-5
Molecular Formula:C₁₅H₁₃BrN₄O₂
Molecular Weight:361.198
Hs Code.:

Synonyms:(Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

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Technology Process of (Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

There total 6 articles about (Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1383852-27-4
5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carbonitrile

: 1383852-28-5
(Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

Guidance literature:: With hydroxylamine; In dimethyl sulfoxide; at 130 ℃; for 3h; microwave;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1383852-28-5
(Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 2 h / Reflux

3.1: trifluoroacetic anhydride / 1,2-dimethoxyethane / 0.67 h / 20 °C / Inert atmosphere

3.2: 6.5 h / 0 °C / Inert atmosphere

3.3: 16 h / 70 °C / Inert atmosphere

4.1: trichlorophosphate / 1,2-dimethoxyethane / 3 h / 20 °C / Inert atmosphere

4.2: pH 7 / Inert atmosphere

5.1: hydroxylamine hydrochloride / ethanol; water / 2 h / Reflux

6.1: acetic anhydride / 24 h / 140 °C

7.1: hydroxylamine / dimethyl sulfoxide / 3 h / 130 °C / microwave

With hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; trifluoroacetic anhydride; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 1383852-25-2
5-bromo-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 1383852-28-5
(Z)-5-bromo-N'-hydroxy-2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / ethanol; water / 2 h / Reflux

2: acetic anhydride / 24 h / 140 °C

3: hydroxylamine / dimethyl sulfoxide / 3 h / 130 °C / microwave

With hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; In ethanol; water; dimethyl sulfoxide;