6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran

Base Information

• Chemical Name: 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran
• CAS No.: 945772-41-8
• Molecular Formula: C₂₃H₂₆O₇
• Molecular Weight: 414.455
• Mol file: 945772-41-8.mol

Synonyms:6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran

Chemical Property of 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran

There total 9 articles about 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-3-(2-isopropyl-3-methoxy-6-iodophenyl)-1-(3,4,5-trimethoxy)-but-2-ene-1-one → 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran (945772-41-8)

Guidance literature:

With triethylsilane; 2,2'-azobis(2-methylpropionamidine) dihydrochloride; In tetrahydrofuran; at 85 ℃; for 15h; Inert atmosphere;

Reference yield: 48.0%

5-iodo-1,2,3-trimethoxybenzene (25245-29-8) + 2-isopropoxy-3-methoxy-6-iodophenol (905751-80-6) + carbon monoxide (201230-82-2) + 1-propynylmagnesium bromide (16466-97-0,13254-27-8) → 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran (945772-41-8)

Guidance literature:

2-isopropoxy-3-methoxy-6-iodophenol; 1-propynylmagnesium bromide; With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 16 ℃; Inert atmosphere; Industry scale; Reflux;

5-iodo-1,2,3-trimethoxybenzene; carbon monoxide; In dimethyl sulfoxide; at 30 ℃; for 39h; under 51.7162 - 206.865 Torr; Inert atmosphere; Industry scale;

With tributylphosphine; In dimethyl sulfoxide; at 30 ℃; for 0.5h; Product distribution / selectivity; Inert atmosphere; Industry scale;

Reference yield:

5-iodo-1,2,3-trimethoxybenzene (25245-29-8) + C13H16O3 + carbon monoxide (201230-82-2) → 6-methoxy-2-methyl-7-(propan-2-yloxy)-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran (945772-41-8)

Guidance literature:

5-iodo-1,2,3-trimethoxybenzene; C₁₃H₁₆O₃; carbon monoxide; In dimethyl sulfoxide; at 90 ℃; for 17h;

With ammonium chloride; In water; dimethyl sulfoxide;

upstream raw materials:

5-iodo-1,2,3-trimethoxybenzene

carbon monoxide

2-isopropoxy-3-methoxy-6-iodophenol

1-propynylmagnesium bromide

Downstream raw materials:

C₂₀H₂₁O₁₀P

2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan