3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

Base Information

Chemical Name:3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione
CAS No.:1351944-90-5
Molecular Formula:C₁₉H₂₅ClN₂O₅
Molecular Weight:396.871
Hs Code.:

Synonyms:3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

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Chemical Property of 3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

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Technology Process of 3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

There total 11 articles about 3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228462-75-6
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

: 1351944-90-5
3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: With sulfuryl dichloride; sodium hydrogencarbonate; In dichloromethane; at -10 - 20 ℃; for 4.5h;

Reference yield:

: 13612-34-5
2-(2,5-dimethylphenyl)acetic acid

: 1351944-90-5
3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / dichloromethane

2.1: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: sodium methylate / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C

4.2: pH 5 - 6

5.1: sodium hydrogencarbonate; sulfuryl dichloride / dichloromethane / 4.5 h / -10 - 20 °C

With sulfuryl dichloride; oxalyl dichloride; sodium methylate; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1228462-72-3
4-hydroxyamino-1-methoxy-piperidine-4-carbonitrile

: 1351944-90-5
3-chloro-3-(2.5-dimethyl-phenyl)-8-methoxy-1-(methoxymethoxy)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water / 3 h / 0 - 20 °C

2.1: sulfuric acid / 40 h / Reflux

2.2: Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: sodium methylate / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C

4.2: pH 5 - 6

5.1: sodium hydrogencarbonate; sulfuryl dichloride / dichloromethane / 4.5 h / -10 - 20 °C

With sulfuryl dichloride; sulfuric acid; sodium methylate; sodium hydride; sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;