3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

Base Information

Chemical Name:3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one
CAS No.:1228462-75-6
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

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Chemical Property of 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

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Technology Process of 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

There total 11 articles about 3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228462-74-5
4-{[2-(2,5-dimethyl-phenyl)-acetyl]-hydroxy-amino}-1-methoxy-piperidine-4-carboxylic acid methyl ester

: 107-30-2
chloromethyl methyl ether

: 1228462-75-6
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

Guidance literature:: 4-{[2-(2,5-dimethyl-phenyl)-acetyl]-hydroxy-amino}-1-methoxy-piperidine-4-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃;

chloromethyl methyl ether; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

With sodium methylate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2.5h;

Reference yield:

: C₂₀H₃₀N₂O₆

: 1228462-75-6
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

Guidance literature:: C₂₀H₃₀N₂O₆; With sodium methylate; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2.5h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; mineral oil; pH=5 - 6;

Reference yield:

: 1228462-71-2
1-methoxy-piperidin-4-one oxime

: 1228462-75-6
3-(2,5-dimethyl-phenyl)-4-hydroxy-8-methoxy-1-methoxymethoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium dihydrogenphosphate / water / 20 °C

2.1: sodium hydrogencarbonate / ethyl acetate; water / 3 h / 0 - 20 °C

3.1: sulfuric acid / 40 h / Reflux

3.2: Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: sodium methylate / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C

5.2: pH 5 - 6

With potassium dihydrogenphosphate; sulfuric acid; sodium methylate; sodium hydride; sodium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;