(4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

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Chemical Name:(4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide
CAS No.:1558040-85-9
Molecular Formula:C₃₁H₃₀FN₇O₄
Molecular Weight:583.622
Hs Code.:

Synonyms:(4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

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Chemical Property of (4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

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Technology Process of (4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

There total 6 articles about (4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 492426-35-4
1-(4-fluorobenzyl)-1H-pyrazol-3-amine

: 1558040-46-2
(2S,4R)-1-(benzofuran-3-carbonyl)-4-(3-ethyl-1-methyl-1H-pyrazole-5-carboxamido)pyrrolidine-2-carboxylic acid

: 1558040-85-9
(4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm401326j

Reference yield:

: C₁₃H₂₀N₄O₃

: 1558040-85-9
(4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401326j

Reference yield:

: 26308-42-9
3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid

: 1558040-85-9
(4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: lithium hydroxide / tetrahydrofuran; methanol / 20 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401326j