492426-35-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-FLUORO-BENZYL)-1H-PYRAZOL-3-YLAMINE is used as a building block for the development of pharmaceutical drugs. Its distinctive structure contributes to the creation of novel compounds with potential applications in treating various medical conditions.
Used in Agrochemical Industry:
In addition to its pharmaceutical applications, 1-(4-FLUORO-BENZYL)-1H-PYRAZOL-3-YLAMINE is also utilized as a building block in the agrochemical industry. It aids in the development of new compounds that can be used for agricultural purposes, such as pesticides or herbicides, to improve crop yield and protect plants from harmful organisms.

Upstream product

• 1820-80-0 3-aminopyrazole 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 1225445-50-0 [1-(4-fluoro-benzyl)-1H-pyrazol-3-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine 
• 1558040-85-9 (4R)-1-(1-benzofuran-3-ylcarbonyl)-4-{[(3-ethyl-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-N-{1-[(4-fluorophenyl)methyl]-1H-pyrazol-3-yl}-L-prolinamide 

Relevant academic research and scientific papers

Pyrrolidinone derivative as glucokinase activator and preparation method and application thereof

The invention provides a pyrrolidone derivative, and more specifically relates to a compound of the formula (I) or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. These compounds and contain their pharmaceutical compositions useful as glucokinase activators for the treatment of metabolic diseases and disorders. R1 . R2 , R3 , R4 , R5 , X And A are as described in the present invention.

AMINOPYRROLOTRIAZINES AS KINASE INHIBITORS

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

(PYRAZOL-3-YL)-1,3,4-THIADIAZOL-2-AMINE AND (PYRAZOL-3-YL)-1,3,4-THIAZOL-2-AMINE COMPOUNDS

A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

HETEROCYCLIC GAMMA SECRETASE MODULATORS

The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise ad