benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate
CAS No.:1052713-36-6
Molecular Formula:C₂₄H₄₀N₂O₅Si
Molecular Weight:464.678
Hs Code.:

Synonyms:benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

There total 16 articles about benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1052715-76-0,859854-67-4,1549812-60-3
benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxypiperidine-1-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1052713-36-6
benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 20h;

Reference yield: 76.0%

: 1052715-57-7
(3aR,7aS)-tert-butyl 5-(3-aminopyridin-4-yl)-2-oxohexahydro-oxazolo[4,5-c]pyridine-3(2H)-carboxylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1052713-36-6
benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1052713-36-6
benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-(tertbutyldimethylsilyloxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium hydroxide; water / ethanol / 5 h / 70 °C

1.2: 2 h / 20 °C

2.1: Chiralpak AS / n-heptane; ethanol / Resolution of racemate

3.1: dmap; 1H-imidazole / dichloromethane / 20 h / 20 °C

With 1H-imidazole; dmap; ammonium hydroxide; water; In ethanol; n-heptane; dichloromethane;