{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

Base Information

Chemical Name:{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester
CAS No.:955372-59-5
Molecular Formula:C₁₆H₁₃FIN₅O₃
Molecular Weight:469.214
Hs Code.:

Synonyms:{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

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Chemical Property of {5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

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Technology Process of {5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

There total 1 articles about {5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885588-69-2
3-(2-fluoro-4-iodo-phenylamino)-isonicotinic acid hydrazide

: 21055-37-8
methyl isothiocyanatoacetate

: 955372-59-5
{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

Guidance literature:: 3-(2-fluoro-4-iodo-phenylamino)-isonicotinic acid hydrazide; methyl isothiocyanatoacetate; In dichloromethane; for 4h; Heating / reflux;

With methyl iodide; In ethanol; at 20 - 80 ℃;

Reference yield:

: 955372-59-5
{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

: 2-{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-ethanol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield:

: 955372-59-5
{5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester

: {5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid

Guidance literature:: {5-[3-(2-fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; pH=3;