21055-37-8

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-ISOTHIOCYANATOACETATE is used as an active pharmaceutical ingredient for its potential antitumor properties, contributing to the development of new cancer treatments by inhibiting the growth of cancer cells.
Used in Agricultural Industry:
METHYL 2-ISOTHIOCYANATOACETATE is used as a key component in the preparation of herbicides and insecticides, leveraging its pesticidal properties to control and manage pests and weeds in agricultural settings.
Safety Note:
Due to its reactivity and potential health hazards, METHYL 2-ISOTHIOCYANATOACETATE should be handled with care and proper safety measures in a controlled laboratory environment to ensure the safety of workers and the integrity of the compound.

InChI:InChI=1/C4H5NO2S/c1-7-4(6)2-5-3-8/h2H2,1H3

Upstream product

• 463-71-8 thiophosgene 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 75-15-0 carbon disulfide 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 61073-82-3 5c-methyl-5t-phenyl-2-thioxo-oxazolidine-4r-carboxylic acid methyl ester 
• 61073-82-3 5t-methyl-5c-phenyl-2-thioxo-oxazolidine-4r-carboxylic acid methyl ester 
• 149789-77-5 methyl (4-oxo-2-thioxo-1,3-thiazolidine-3-yl)acetate 
• 157550-16-8 (R,S)-(4-amino-phenyl)-(3-ethoxycarbonylmethyl-ureido)acetic acid methyl ester 
• 1404554-41-1 C₂₁H₁₉N₃O₃S 
• 1381953-72-5 methyl 2-(3-phenylisoquinolin-1-ylamino)acetate 
• 1139818-64-6 (S)-methyl-2-(3-(1-(4-fluorophenyl)ethyl)thioureido)acetate 
• 1115389-36-0 C₁₈H₂₆FN₃O₄S 
• 1115389-46-2 C₁₃H₁₇FN₂O₃S 
• 136620-74-1 methyl(4S,5R)-5-phenyl-2-thioxooxazolidine-4-carboxylate 
• 1027637-92-8 ethyl (E)-2-[N-(methoxycarbonylmethyl)thiocarbamoyl]-3-phenylamino-but-2-enoate 

Relevant academic research and scientific papers

IMPROVED INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME

Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically accept

Versatile synthesis of 2′-amino-2′-deoxyuridine derivatives with a 2′-amino group carrying linkers possessing a reactive terminal functionality

2,2′-Anhydrouridine has been successfully converted into the appropriate 2′-amino-2′-deoxyuridine derivatives in a reaction with isothiocyanates obtained from amino acids or α,ω-diaminoalkanes. The initially formed oxazolidine-2-thione ring is cleaved under basic conditions into the corresponding 2′-amino(substituted)-2′-deoxyuridine derivatives. The implemented additional terminal functionality in the substituent attached to the 2′-amino group allows further modifications with e.g., fluorophore moiety.

A facile one-pot synthesis of selenoureidopeptides employing lialhseh through staudinger aza-wittig-type reaction

A one-pot protocol for the synthesis of selenoureidopeptides employing lithium aluminum hydride hydroselenide (LiAlHSeH) as a selenating agent via a Staudinger aza-Wittig-type reaction is reported. The protocol involves the use of Nα-protected aminoalkyl azides and isothicyanato esters to afford the desired products in good yields. This protocol is a direct approach to the synthesis of selenourea compounds that avoids the synthesis of isoselenocyanates and does not require multistep synthesis.

Novel pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as highly effective catalysts for the asymmetric Michael addition

The synthesis of novel organocatalysts consisting of a pyrrolidine moiety and a thiohydantoin or a thioxotetrahydropyrimidinone ring is described. The compound combining the pyrrolidine with the thioxotetrahydropyrimidinone was found to be a highly effect

GAMMA SECRETASE MODULATORS

In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing

GAMMA SECRETASE MODULATORS

In its many embodiments, the present invention provides a novel class of 5-membered, nitrogen-containing heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such

Novel selenium catalyzed synthesis of isothiocyanates from isocyanides and elemental sulfur

A variety of aliphatic and aromatic isothiocyanates were synthesized in good to excellent yields from corresponding isocyanides and elemental sulfur under mild conditions by use of catalytic amounts of elemental selenium.

Dithiocarboxylation of α-Nitrogen-Carbanions

Dithiocarbamic acid esters 1 with CH-acidic methylene group adjacent to nitrogen react in the system dimethylformamide + 2 equivalents sodium tert. butoxide with carbon disulphide yielding 1,3-thiazoline-2-thiones 3. 2,5-Bis(alkylthio)-1,3-thiazoles 6 are available via dithiocarboxylation of isothiocyanate 5. - Keywords: Dithiocarbamic acid esters; 1,3-Thiazoline-2-thiones; 2-Alkylthio-1,3-thiazoles; 1,3-Thiazole-derivatives.