21055-37-8Relevant articles and documents
IMPROVED INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME
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Paragraph 00106, (2020/10/21)
Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically accept
A facile one-pot synthesis of selenoureidopeptides employing lialhseh through staudinger aza-wittig-type reaction
Sharanabai, Kupendra M.,Prabhu, Girish,Panduranga, Veladi,Sureshbabu, Vommina V.
, p. 801 - 806 (2015/03/14)
A one-pot protocol for the synthesis of selenoureidopeptides employing lithium aluminum hydride hydroselenide (LiAlHSeH) as a selenating agent via a Staudinger aza-Wittig-type reaction is reported. The protocol involves the use of Nα-protected aminoalkyl azides and isothicyanato esters to afford the desired products in good yields. This protocol is a direct approach to the synthesis of selenourea compounds that avoids the synthesis of isoselenocyanates and does not require multistep synthesis.
GAMMA SECRETASE MODULATORS
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Page/Page column 231; 232, (2009/04/25)
In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing
