2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate

Base Information

Chemical Name:2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate
CAS No.:148692-19-7
Molecular Formula:C₁₇H₂₃NO₃S
Molecular Weight:321.441
Hs Code.:

Synonyms:2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate

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Chemical Property of 2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate

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Technology Process of 2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate

There total 2 articles about 2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 100-39-0
benzyl bromide

: 104654-63-9
methyl (2R,4R)-2-(tert-butyl)-1,3-thiazolidine-3-formyl-4-carboxylate

: 148692-19-7
2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate

Guidance literature:: benzyl bromide; methyl (2R,4R)-2-(tert-butyl)-1,3-thiazolidine-3-formyl-4-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -25 ℃;

With acetic acid; In tetrahydrofuran;

Reference yield:

: 872434-89-4
methyl 4R-2-tert-butyl-1,3-thiazolidine-4-carboxylate

: 148692-19-7
2R,4R-methyl 2-tert-butyl-1,3-thiazolidine-3-formyl-4-benzyl-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / acetic anhydride, formic acid / a) 0-5 deg C to room temperature, b) overnight

2: 1) lithium diisopropylamide, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1) THF, hexanes, -90 deg C, 0.75 h, 2) a) -90 deg C, 2 h, b) to room temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; formic acid; acetic anhydride; lithium diisopropyl amide;
DOI:10.1016/S0040-4020(01)86313-4