DL-ALANINOL HYDROCHLORIDE

Base Information

• Chemical Name: DL-ALANINOL HYDROCHLORIDE
• CAS No.: 17016-92-1
• Molecular Formula: C₃H₉NO*ClH
• Molecular Weight: 111.572
• Mol file: 17016-92-1.mol

Synonyms:1-Propanol, 2-amino-, hydrochloride;2-Aminopropan-1-ol hydrochloride;DL-Alaninol HCL;DL-Alaninol hydrochloride;AC1L38CF;AR-1C5502;

Chemical Property of DL-ALANINOL HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: Off-white to tan crystal
• Vapor Pressure: 0.0766mmHg at 25°C
• Boiling Point: 174.5 °C at 760 mmHg
• Flash Point: 83.9 °C
• PSA: 46.25000
• LogP: 0.82820

Purity/Quality:

99% ^*data from raw suppliers

DL-Alaninol hydrochloride ≥98%, crystalline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-ALANINOL HYDROCHLORIDE

There total 2 articles about DL-ALANINOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,2,2-trichloro-acetimidic acid propyl ester (99418-53-8) → dl-2-amino-1-propanol hydrochloride (6170-23-6,17016-92-1)

Guidance literature:

2,2,2-trichloro-acetimidic acid propyl ester; With N-iodo-succinimide; In 1,2-dichloro-ethane; at 110 ℃; for 3h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; at 20 ℃; for 5h; Inert atmosphere; Sealed tube;

DOI:10.1039/c7cc08897c

Reference yield:

(1S)-2-methoxy-1-methylethylamine (37143-54-7,99636-38-1,123410-24-2,99636-32-5) → (S)-alaninol hydrochloride (17016-91-0,17016-92-1)

Guidance literature:

With hydrogenchloride; In water; at 135 ℃; for 2h; under 22502.3 Torr; Product distribution / selectivity; Inert atmosphere; Autoclave;

Reference yield:

(S)-alaninol hydrochloride (17016-91-0,17016-92-1) + 2-Allyl-2-(2-nitrophenyl)-1,3-cyclohexanedione (138040-07-0) → (3aR*,7a*)-1-<(1S)-2-hydroxy-1-methylethyl>-3a-(o-nitrophenyl)octahydroindol-4-one

Guidance literature:

With sodium cyanoborohydride; ozone; Yield given. Multistep reaction; 1.) methylene chloride, -78 deg C, 5 h, 2.) methanol, 4 h;

DOI:10.1016/S0040-4020(96)00065-8

upstream raw materials:

2,2,2-trichloro-acetimidic acid propyl ester

(1S)-2-methoxy-1-methylethylamine

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF (S)-2-AMINO-1-PROPANOL (L-ALANINOL) FROM (S)-1-METHOXY-2-PROPYLAMINE". Page/Page column 3. . Retrieved 2010/10/03.