138040-07-0

Upstream product

• 138040-06-9 3-allyloxy-2-(o-nitrophenyl)-2-cyclohexenone 
• 138040-05-8 3-hydroxy-2-(2-nitrophenyl)cyclohex-2-enone 
• 106-95-6 allyl bromide 
• 504-02-9 1,3-cylohexanedione 
• 591-87-7 Allyl acetate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 30182-67-3 1,3-Cyclohexanedione 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 138040-12-7 trans-1-benzyl-3a-(o-nitrophenyl)octahydroindol-4-one 
• 138040-12-7 cis-1-benzyl-3a-(o-nitrophenyl)octahydroindol-4-one 
• 138040-35-4 7-(2-Nitro-phenyl)-oxonane-2,6-dione 
• 176042-32-3 2-(formylmethyl)-2-(o-nitrophenyl)-1,2-cyclohexanedione 
• 192431-33-7 (3aR,7aS)-N-[(S)-α-Methylbenzyl]-3a-(2-nitrophenyl)octahydroindol-4-one 

Relevant academic research and scientific papers

Domino Ring Expansion: Regioselective Access to 9-Membered Lactones with a Fused Indole Unit from 2-Nitrophenyl-1,3-cyclohexanediones

The domino anionic fragmentation of 2-nitrophenyl-1,3-cyclohexanediones containing an electrophilic appendage such as aldehyde and epoxide is disclosed. This reaction, initiated by a series of nucleophiles, involves the generation of an intermediate hydroxylate followed by the regioselective formation and fragmentation of an intermediate lactolate into enolate. This strategy, devoid of any protecting group, enlarges the initial ring and provides an original access to decorated 9-membered lactones with a fused indole unit.

Total synthesis of (-)-strychnine via the Wieland - Gumlich aldehyde

Fifteen steps suffice for an enantioselective total synthesis of (-)- strychnine (1) from 1,3-cyclohexanedione. The key steps are the easy generation of the enantiopure intermediate 2, the closure of the piperidine ring by a reductive Heck reaction, and the elaboration of the indoline nucleus in an advanced synthetic stage. TBDMS = tert-butyldimethylsilyl.

3a-(o-nitrophenyl)octahydroindol-4-ones: Synthesis and spectroscopic analysis

A short entry to 3a-(o-nitrophenyl)octahydroindol-4-ones employing ozonolysis and double reductive amination of 2-allyl-2-(o-nitrophenyl)-1,3-cyclohexanedione (9) is described. The symmetric dione 9 is synthesized in a 50% overall yield from 1,3-cyclohexa

cis-3a-(o-nitrophenyl)octahydroindol-4-one. Building blocks for the synthesis of indole alkaloids

A four-step synthesis of 3a-aryloctahydroindol-4-ones (1) in which the key step is the ozonolysis of 2-allyl-2-(o-nitrophenyl)-1,3-cyclohexanedione (5) followed by reductive aminocyclization was been accomplished. An asymmetric synthesis of the bicyclic s