ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

Base Information

Chemical Name:ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid
CAS No.:158461-11-1
Molecular Formula:C₁₈H₁₅Br₂FN₂O₄S
Molecular Weight:534.201
Hs Code.:

Synonyms:ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

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Chemical Property of ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

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Technology Process of ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

There total 5 articles about ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 122185-96-0
[3-(4-Bromo-2-fluoro-benzyl)-6-methyl-2,4-dioxo-3,4-dihydro-2H-thieno[2,3-d]pyrimidin-1-yl]-acetic acid ethyl ester

: 158461-11-1
ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

Guidance literature:: With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; water; at 40 ℃; for 6h;
DOI:10.1016/0223-5234(93)90112-R

Reference yield:

: 4815-32-1
ethyl 2-amino-5-methylthiophene-3-carboxylate

: 158461-11-1
ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) dioxane, RT, 1 h, 2.) dioxane, RT, 12 h

2: CH₃ONA / methanol / 2 h / Heating

3: 1.) NaH / 1.) RT, 5 h, 2.) RT, 17 h

4: 34 percent / NBS, benzoyl peroxide / H₂O; CCl₄ / 6 h / 40 °C

With N-Bromosuccinimide; Perbenzoic acid; sodium methylate; sodium hydride; In methanol; tetrachloromethane; water;
DOI:10.1016/0223-5234(93)90112-R

Reference yield:

: 112734-22-2
4-bromo-2-fluorobenzylamine

: 158461-11-1
ethyl 3-(4-bromo-2-fluorobenzyl)-6-bromomethyl-2,4-dioxothieno<2,3-d>pyrimidin-1-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) dioxane, RT, 1 h, 2.) dioxane, RT, 12 h

2: CH₃ONA / methanol / 2 h / Heating

3: 1.) NaH / 1.) RT, 5 h, 2.) RT, 17 h

4: 34 percent / NBS, benzoyl peroxide / H₂O; CCl₄ / 6 h / 40 °C

With N-Bromosuccinimide; Perbenzoic acid; sodium methylate; sodium hydride; In methanol; tetrachloromethane; water;
DOI:10.1016/0223-5234(93)90112-R