Technology Process of (R)-2-(1-(2-methoxy-5-methylphenyl)-1-phenylbut-3-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 3 articles about (R)-2-(1-(2-methoxy-5-methylphenyl)-1-phenylbut-3-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-1-(2-methoxy-5-methylphenyl)but-3-enyl diisopropylcarbamate;
With
sec.-butyllithium;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
With
magnesium bromide;
In
methanol; diethyl ether; hexane; cyclohexane;
at -78 - 20 ℃;
for 16.0833h;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1139/v2012-069
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate
2.1: Inert atmosphere; Schlenk technique
3.1: triethylamine / toluene / 2 h / 150 °C / Inert atmosphere
4.1: sec.-butyllithium / diethyl ether; cyclohexane; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique
4.2: 2 h / -78 °C / Inert atmosphere; Schlenk technique
4.3: 16.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
With
sec.-butyllithium; potassium carbonate; triethylamine;
In
diethyl ether; hexane; cyclohexane; toluene;
DOI:10.1139/v2012-069
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Inert atmosphere; Schlenk technique
2.1: triethylamine / toluene / 2 h / 150 °C / Inert atmosphere
3.1: sec.-butyllithium / diethyl ether; cyclohexane; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique
3.2: 2 h / -78 °C / Inert atmosphere; Schlenk technique
3.3: 16.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
With
sec.-butyllithium; triethylamine;
In
diethyl ether; hexane; cyclohexane; toluene;
DOI:10.1139/v2012-069
