C₂₁H₂₁NO

Base Information

• Chemical Name: C₂₁H₂₁NO
• CAS No.: 1392323-14-6
• Molecular Formula: C₂₁H₂₁NO
• Molecular Weight: 303.404
• Mol file: 1392323-14-6.mol

Synonyms:C₂₁H₂₁NO

Chemical Property of C₂₁H₂₁NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₁NO

There total 3 articles about C₂₁H₂₁NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H23BO2 (1392323-63-5) + o-iodobenzanilide (15310-02-8) → C21H21NO (1392323-14-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In 1,4-dioxane; water; at 90 ℃; for 13h; Inert atmosphere;

DOI:10.1021/ja305795x

Reference yield:

5,6-dibromo-1-cyclooctene (24165-06-8) → C21H21NO (1392323-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: morpholine; dimethyl sulfoxide / benzene / 18 h / Reflux; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium phenolate; triphenylphosphine; potassium bromide / toluene / 7 h / 60 °C / Inert atmosphere

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 13 h / 90 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; morpholine; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; potassium phenolate; palladium diacetate; dimethyl sulfoxide; triphenylphosphine; potassium bromide; In 1,4-dioxane; water; toluene; benzene;

DOI:10.1021/ja305795x

Reference yield:

1-bromo-1,5-cyclooctadiene (57559-44-1) → C21H21NO (1392323-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium phenolate; triphenylphosphine; potassium bromide / toluene / 7 h / 60 °C / Inert atmosphere

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 13 h / 90 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; potassium phenolate; palladium diacetate; triphenylphosphine; potassium bromide; In 1,4-dioxane; water; toluene;

DOI:10.1021/ja305795x

upstream raw materials:

5,6-dibromo-1-cyclooctene

C₁₄H₂₃BO₂

o-iodobenzanilide

1-bromo-1,5-cyclooctadiene

Downstream raw materials:

C₂₁H₂₀BrNO

Refernces