N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

Base Information

Chemical Name:N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride
CAS No.:1446841-33-3
Molecular Formula:C₂₀H₂₄N₂O*ClH
Molecular Weight:344.884
Hs Code.:

Synonyms:N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

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Chemical Property of N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

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Technology Process of N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

There total 9 articles about N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: C₂₀H₂₆N₂O₂

: 1446841-33-3
N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

Guidance literature:: C₂₀H₂₆N₂O₂; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 16h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; Inert atmosphere;
DOI:10.1021/ja405833m

Reference yield:

: 1-(2-(dimethylamino)ethyl)-4-phenyl-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one

: 1446841-33-3
N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

Guidance literature:: 1-(2-(dimethylamino)ethyl)-4-phenyl-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 16h;

With hydrogenchloride; In diethyl ether; water;

Reference yield:

: 95-48-7,77504-84-8
ortho-cresol

: 1446841-33-3
N,N-dimethyl-2-(2-oxo-4-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 2 h / Inert atmosphere; Reflux

3.1: tetrabutylammonium acetate; cesium fluoride; 18-crown-6 ether; (5aR,10bS)-2-(2,6-diethylphenyl)-4,5a,6,10b-tetrahydroindeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate / tetrahydrofuran / 12 h / -18 °C / Inert atmosphere

4.1: sulfuric acid / 1.5 h / 75 °C

5.1: triethylamine / dichloromethane / 1.5 h / -20 °C / Inert atmosphere

6.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 0.42 h / 140 °C

7.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 16 h / 21 °C / Inert atmosphere

8.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

8.2: Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; 18-crown-6 ether; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); sulfuric acid; (5aR,10bS)-2-(2,6-diethylphenyl)-4,5a,6,10b-tetrahydroindeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; tetrabutylammonium acetate; palladium diacetate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; cesium fluoride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja405833m