1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone

Base Information

• Chemical Name: 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone
• CAS No.: 33095-83-9
• Molecular Formula: C₁₈H₁₇N₃O₅
• Molecular Weight: 355.35
• Mol file: 33095-83-9.mol

Synonyms:1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property of 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone

There total 5 articles about 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

3-nitro-benzaldehyde (99-61-6) + N-isopropyl-N-[3,4-(methylenedioxy)phenyl]urea (33095-94-2) → 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone (33095-83-9)

Guidance literature:

With methanesulfonic acid; In toluene; for 20h; Heating;

DOI:10.1002/jhet.5570190639

Reference yield:

N-isopropyl-3,4-(methylenedioxy)aniline (10368-14-6) → 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone (33095-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / HOAc / 15 h / Ambient temperature

2: 59 percent / CH₃SO₃H / toluene / 21 h / Heating

With methanesulfonic acid; acetic acid; In toluene;

DOI:10.1021/jm00351a022

Reference yield:

benzo[1,3]dioxolo-5-ylamine (14268-66-7) → 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone (33095-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / Et₃N / methanol / 52 h / Heating

2: 82 percent / HOAc / 15 h / Ambient temperature

3: 59 percent / CH₃SO₃H / toluene / 21 h / Heating

With methanesulfonic acid; acetic acid; triethylamine; In methanol; toluene;

DOI:10.1021/jm00351a022

upstream raw materials:

3-nitro-benzaldehyde

N-isopropyl-N-[3,4-(methylenedioxy)phenyl]urea

N-isopropyl-3,4-(methylenedioxy)aniline

benzo[1,3]dioxolo-5-ylamine

Downstream raw materials:

1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-2(1H)-quinazolinone