5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Base Information

Chemical Name:5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one
CAS No.:1229019-16-2
Molecular Formula:C₂₀H₂₇ClN₄O₄S
Molecular Weight:454.978
Hs Code.:

Synonyms:5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Suppliers and Price of 5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

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Chemical Property of 5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

There total 7 articles about 5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1229017-03-1
6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)-phenyl]pyrimidin-4(3H)-one

: 1229019-16-2
5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: With pyridine; chlorine; In dichloromethane; for 0.0333333h; Cooling with ice;

Reference yield:

: 1229019-36-6
5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide

: 1229019-16-2
5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

2: pyridine; chlorine / dichloromethane / 0.02 h / 0 °C

With pyridine; chlorine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200644r

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1229019-16-2
5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 0 - 20 °C

2.2: pH 2 - 3

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

4.1: pyridine; chlorine / dichloromethane / 0.02 h / 0 °C

With pyridine; chlorine; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200644r