5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide

Base Information

• Chemical Name: 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide
• CAS No.: 1229019-36-6
• Molecular Formula: C₁₅H₂₄N₄O₃S
• Molecular Weight: 340.447
• Mol file: 1229019-36-6.mol

Synonyms:5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide

Chemical Property of 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide

There total 4 articles about 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propoxy-5-(4-methylpiperazin-1-yl)sulphonylbenzonitrile (1229019-31-1) → 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide (1229019-36-6)

Guidance literature:

2-propoxy-5-(4-methylpiperazin-1-yl)sulphonylbenzonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2 - 3;

DOI:10.1021/jm200644r

Reference yield:

1-methyl-piperazine (109-01-3) → 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide (1229019-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 0 - 20 °C

2.2: pH 2 - 3

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm200644r

Reference yield:

C10H10ClNO3S (1229020-03-4) → 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide (1229019-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 0 - 20 °C

2.2: pH 2 - 3

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm200644r

upstream raw materials:

1-methyl-piperazine

C₁₀H₁₀ClNO₃S

2-propoxy-5-(4-methylpiperazin-1-yl)sulphonylbenzonitrile

2-propoxybenzonitrile

Downstream raw materials:

5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

5-bromo-6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimidin-4(3H)-one

5-iodo-6-ethyl-2-[2-n-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)-phenyl]pyrimidin-4(3H)-one