1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

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Chemical Name:1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione
CAS No.:1447068-04-3
Molecular Formula:C₃₁H₃₂N₂O₆
Molecular Weight:528.605
Hs Code.:

Synonyms:1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

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Chemical Property of 1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

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Technology Process of 1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

There total 4 articles about 1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1246763-90-5
(thymin-1-yl) 1,2,3-trideoxy-β-L-erythro-hexopyranoside

: 14470-28-1
mono-4-methoxytrityl chloride

: 1447068-04-3
1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

Guidance literature:: In pyridine; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201301659

Reference yield:

: 1246763-83-6
1,4,6-tri-O-acetyl-2,3-dideoxy-L-erythro-hexopyranose

: 1447068-04-3
1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / dichloromethane / 1.33 h / -20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -78 °C / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / acetonitrile

4: sodium methylate; methanol

5: pyridine / 20 °C / Inert atmosphere

With methanol; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; sodium methylate; 3-chloro-benzenecarboperoxoic acid; In pyridine; dichloromethane; acetonitrile;
DOI:10.1002/anie.201301659

Reference yield:

: 1246763-86-9
4,6-di-O-acetyl-1,2,3-trideoxy-1-(phenylsulfinyl)-L-erythro-hexopyranose

: 1447068-04-3
1-(5-hydroxy-6-[(4-methoxyphenyl)(diphenyl)methoxy]methyltetrahydro-2H-2-pyranyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilyl trifluoromethanesulfonate / acetonitrile

2: sodium methylate; methanol

3: pyridine / 20 °C / Inert atmosphere

With methanol; trimethylsilyl trifluoromethanesulfonate; sodium methylate; In pyridine; acetonitrile;
DOI:10.1002/anie.201301659