(E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

Base Information

Chemical Name:(E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester
CAS No.:82731-54-2
Molecular Formula:C₁₈H₂₄O₂SSi
Molecular Weight:332.539
Hs Code.:

Synonyms:(E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

Chemical Property:

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Technology Process of (E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

There total 6 articles about (E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5927-18-4
trimethyl phosphonoacetate

: 82707-24-2
4-Phenylsulfanyl-6-trimethylsilanyl-hex-5-ynal

: 82731-54-2
(E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/ja00384a079

Reference yield:

: 5651-88-7
phenyl propargyl sulfide

: 82731-54-2
(E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) EtMgBr / 1.) THF, -78 deg C, 2.) -78 deg C

2: 90 percent / LDA, HMPA / tetrahydrofuran / -78 °C

3: 75 percent / AcOH / tetrahydrofuran; H₂O / 40 °C

4: 80 percent / SO₃*pyr, Et₃N / dimethylsulfoxide / 25 °C

5: 76 percent / NaH / tetrahydrofuran / 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine-SO₃ complex; ethylmagnesium bromide; sodium hydride; acetic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/ja00384a079

Reference yield:

: 108-98-5
thiophenol

: 82731-54-2
(E)-6-Phenylsulfanyl-8-trimethylsilanyl-oct-2-en-7-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DBU / tetrahydrofuran / -10 °C

2: 1.) EtMgBr / 1.) THF, -78 deg C, 2.) -78 deg C

3: 90 percent / LDA, HMPA / tetrahydrofuran / -78 °C

4: 75 percent / AcOH / tetrahydrofuran; H₂O / 40 °C

5: 80 percent / SO₃*pyr, Et₃N / dimethylsulfoxide / 25 °C

6: 76 percent / NaH / tetrahydrofuran / 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine-SO₃ complex; ethylmagnesium bromide; sodium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/ja00384a079