[3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol

Base Information

• Chemical Name: [3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol
• CAS No.: 887775-37-3
• Molecular Formula: C₂₄H₂₂F₃NO
• Molecular Weight: 397.44

Synonyms:[3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol

Chemical Property of [3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol

Chemical Property:

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Technology Process of [3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol

There total 1 articles about [3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-bromo-benzyl)-7-trifluoromethyl-1,2,3,4-tetrahydro-quinoline (887775-36-2) + p-hydroxymethylphenylboronic acid (59016-93-2) → [3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol (887775-37-3)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 2h;

Reference yield:

[3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol (887775-37-3) + methyl 5-hydroxy-3-pyridinecarboxylate (30766-22-4) → 5-[3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-ylmethoxy]-nicotinic acid methyl ester

Guidance literature:

With 1H-imidazole; 1,1'-azodicarbonyl-dipiperidine; trimethylphosphane; In dichloromethane; toluene; at 20 ℃; for 1h;

Reference yield:

[3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-yl]-methanol (887775-37-3) + N-[(tert-butoxy)carbonyl]-L-cysteine methyl ester (172749-96-1) → 2-tert-butoxycarbonylamino-3-[3'-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)-biphenyl-4-ylmethylsulfanyl]-propionic acid methyl ester

Guidance literature:

With 1H-imidazole; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In dichloromethane; toluene; at 20 ℃; for 1h;

upstream raw materials:

1-(3-bromo-benzyl)-7-trifluoromethyl-1,2,3,4-tetrahydro-quinoline

p-hydroxymethylphenylboronic acid

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