30766-22-4Relevant articles and documents
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs
Xu, Mingshuo,Wang, Yu,Yang, Feipu,Wu, Chunhui,Wang, Zhen,Ye, Bin,Jiang, Xiangrui,Zhao, Qingjie,Li, Jianfeng,Liu, Yongjian,Zhang, Junchi,Tian, Guanghui,He, Yang,Shen, Jingshan,Jiang, Hualiang
supporting information, p. 606 - 611 (2018/02/06)
In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover novel antipsychotics, herein we reported the evaluation of a series of pyridinecarboxamide derivatives. The most promising compound 7h not only held good activities on dopamine D2, serotonin 5-HT1A and 5-HT2A receptors, but also exhibited low potency for α1A, H1 and 5-HT2C receptors, indicating a low propensity of side effects like orthostatic hypotension and weight gain. Furthermore, 7h exhibited more potent antipsychotic-like effect than aripiprazole in behavioral studies. The preliminary results were promising enough for further research around this scaffold.
MODIFIED COMPOUND OF ANDROGRAPHOLIDE
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Paragraph 0236-0238, (2019/01/04)
The present disclosure discloses a modified compound of andrographolide, and particularly discloses a compound shown in formula (I) and (II) or a pharmaceutically acceptable salt thereof.
SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS
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Page/Page column 52, (2015/11/10)
The invention provides a chemical entity of Formula (I): wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of
