1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole
• CAS No.: 1355330-32-3
• Molecular Formula: C₂₂H₂₇N₃O₈
• Molecular Weight: 461.472

Synonyms:1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Chemical Property of 1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Chemical Property:

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Technology Process of 1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

There total 2 articles about 1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

3,4,5-trimethoxyphenylacetylene (53560-33-1) + 1-azido-4-methoxy-2,3-bis(methoxymethoxy)benzene (1355330-27-6) → 1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (1355330-32-3)

Guidance literature:

3,4,5-trimethoxyphenylacetylene; With ethylmagnesium chloride; In tetrahydrofuran; at 50 ℃; for 0.25h; Inert atmosphere;

1-azido-4-methoxy-2,3-bis(methoxymethoxy)benzene; In tetrahydrofuran; at 50 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.11.010

Reference yield:

1-bromo-4-methoxy-2,3-bis(methoxymethoxy)-benzene (290347-62-5) → 1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (1355330-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 15 h / -78 - 20 °C / Inert atmosphere

2.1: ethylmagnesium chloride / tetrahydrofuran / 0.25 h / 50 °C / Inert atmosphere

2.2: 3 h / 50 °C / Inert atmosphere

With n-butyllithium; ethylmagnesium chloride; In tetrahydrofuran;

DOI:10.1016/j.bmc.2011.11.010

Reference yield: 86.0%

1-(4-methoxy-2,3-bis(methoxymethoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (1355330-32-3) → 3-methoxy-6-(5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-1-yl)benzene-1,2-diol (1355330-13-0)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2011.11.010

upstream raw materials:

3,4,5-trimethoxyphenylacetylene

1-azido-4-methoxy-2,3-bis(methoxymethoxy)benzene

1-bromo-4-methoxy-2,3-bis(methoxymethoxy)-benzene

Downstream raw materials:

3-methoxy-6-(5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-1-yl)benzene-1,2-diol

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