3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol

Base Information

• Chemical Name: 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol
• CAS No.: 1420468-68-3
• Molecular Formula: C₁₉H₁₄Cl₂N₄O₂
• Molecular Weight: 401.252
• Mol file: 1420468-68-3.mol

Synonyms:3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol

Chemical Property of 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol

There total 10 articles about 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

ethyl 3-oxo-3-(4-pyridyl)propanoate (26377-17-3) + 4-(2,3-dichlorobenzyl)-5-methoxy-1H-pyrazol-3-amine (1420468-67-2) → 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol (1420468-68-3)

Guidance literature:

With acetic acid; at 100 ℃; for 4h;

DOI:10.1021/ml300330m

Reference yield:

3-amino-4-(2,3-dichlorobenzyl)-1H-pyrazol-5-ol (1420468-64-9) → 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol (1420468-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid / 16 h / Reflux

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C

2.2: 2 h / 20 °C

3.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 - 50 °C

4.1: acetic acid / 4 h / 100 °C

With di-isopropyl azodicarboxylate; hydrazine hydrate; acetic acid; triphenylphosphine; In tetrahydrofuran;

DOI:10.1021/ml300330m

Reference yield:

2-(4-(2,3-dichlorobenzyl)-3-hydroxy-1H-pyrazol-5-yl)isoindoline-1,3-dione (1420468-65-0,1426098-81-8) → 3-(2,3-dichlorobenzyl)-2-methoxy-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol (1420468-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 0 °C

1.2: 2 h / 20 °C

2.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 - 50 °C

3.1: acetic acid / 4 h / 100 °C

With di-isopropyl azodicarboxylate; hydrazine hydrate; acetic acid; triphenylphosphine; In tetrahydrofuran;

DOI:10.1021/ml300330m

upstream raw materials:

ethyl 2-cyano-3-(2,3-dichlorophenyl)propanoate

3-amino-4-(2,3-dichlorobenzyl)-1H-pyrazol-5-ol

2-(4-(2,3-dichlorobenzyl)-3-hydroxy-1H-pyrazol-5-yl)isoindoline-1,3-dione

2-(4-(2,3-dichlorobenzyl)-3-methoxy-1H-pyrazol-5-yl)isoindoline-1,3-dione