N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine
CAS No.:1438075-28-5
Molecular Formula:C₂₄H₂₆ClFN₄O₃
Molecular Weight:472.947
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

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Chemical Property of N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

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Technology Process of N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

There total 10 articles about N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.04%

: 5-(3-chloropropyl)hexahydro-1H-furo[3,4-c]pyrrole

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1438075-28-5
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

Guidance literature:: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

5-(3-chloropropyl)hexahydro-1H-furo[3,4-c]pyrrole; In N,N-dimethyl-formamide; at 80 ℃; for 14h; Inert atmosphere;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438075-28-5
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 5 h / 88 °C

2.1: water; sodium hydroxide / methanol / 6 h / 20 °C

3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 14 h / 80 °C / Inert atmosphere

With water; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 179688-53-0
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

: 1438075-28-5
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)propoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C

2.1: isopropyl alcohol / 5 h / 88 °C

3.1: water; sodium hydroxide / methanol / 6 h / 20 °C

4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 14 h / 80 °C / Inert atmosphere

With thionyl chloride; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;