Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Base Information

Chemical Name:Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester
CAS No.:373389-65-2
Molecular Formula:C₄₀H₆₁NO₄
Molecular Weight:619.929
Hs Code.:

Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Synonyms:Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Suppliers and Price of Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

There total 12 articles about Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 373389-60-7
Phenyl-carbamic acid (2S,4aS,5R,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-oxo-decahydro-naphthalen-2-yl ester

: 373389-65-2
Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; benzene; for 2h; Heating;
DOI:10.1021/ol016543a

Reference yield:

: 4128-17-0
(2E,6E)-farnesyl acetate

: 373389-65-2
Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 72 percent / MeSO₂NH₂; K₂OsO₄*2H₂O; K₃Fe(CN)6 / chiral monocinchona derivative C₇₀H₆₃N₅O₃; K₂CO₃ / 2-methyl-propan-2-ol; H₂O / 4 h / 0 °C

2.1: p-TsOH / 0.5 h / 23 °C

3.1: K₂CO₃ / methanol / 1 h / 23 °C

4.1: MeSO₂Cl; Et₃N / CH₂Cl₂ / 1.5 h / -42 - 0 °C

4.2: LiBr / tetrahydrofuran / 1 h / 0 °C

5.1: LDA; CuI / tetrahydrofuran / -110 - -30 °C

5.2: 92 percent / tetrahydrofuran / 1 h / -30 °C

6.1: LiAlH₄ / diethyl ether / 0.5 h / Heating

7.1: Ph₃P; imidazole; I₂ / CH₂Cl₂ / 0.5 h / 23 °C

8.1: 1.10 g / dimethylformamide / 24 h / 23 °C

9.1: BuLi / tetrahydrofuran; diethyl ether; hexane / 0.17 h / -78 °C

9.2: 75 percent / tetrahydrofuran; diethyl ether; hexane / -78 - 0 °C

10.1: Me₂AlCl₂ / CH₂Cl₂ / 0.25 h / -94 °C

10.2: TBAF / tetrahydrofuran / 15 h / 50 °C

10.3: 75 percent / KOH / methanol / 3 h / Heating

11.1: 75 percent / pyridine / 12 h / 23 °C

12.1: 90 percent / KOtBu / benzene; tetrahydrofuran / 2 h / Heating

With 1H-imidazole; potassium osmate(VI); copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; methanesulfonamide; Me₂AlCl₂; potassium tert-butylate; iodine; potassium carbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); lithium diisopropyl amide; chiral monocinchona derivative C₇₀H₆₃N₅O₃; potassium carbonate; In tetrahydrofuran; pyridine; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1021/ol016543a

Reference yield:

: 130790-63-5
(2E,6E)-3,7-dimethyl-9-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)nona-2,6-dienyl acetate

: 373389-65-2
Phenyl-carbamic acid (2S,4aR,5S,8aR)-5-[(3E,7E)-4,8-dimethyl-10-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-deca-3,7-dienyl]-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: K₂CO₃ / methanol / 1 h / 23 °C

2.1: MeSO₂Cl; Et₃N / CH₂Cl₂ / 1.5 h / -42 - 0 °C

2.2: LiBr / tetrahydrofuran / 1 h / 0 °C

3.1: LDA; CuI / tetrahydrofuran / -110 - -30 °C

3.2: 92 percent / tetrahydrofuran / 1 h / -30 °C

4.1: LiAlH₄ / diethyl ether / 0.5 h / Heating

5.1: Ph₃P; imidazole; I₂ / CH₂Cl₂ / 0.5 h / 23 °C

6.1: 1.10 g / dimethylformamide / 24 h / 23 °C

7.1: BuLi / tetrahydrofuran; diethyl ether; hexane / 0.17 h / -78 °C

7.2: 75 percent / tetrahydrofuran; diethyl ether; hexane / -78 - 0 °C

8.1: Me₂AlCl₂ / CH₂Cl₂ / 0.25 h / -94 °C

8.2: TBAF / tetrahydrofuran / 15 h / 50 °C

8.3: 75 percent / KOH / methanol / 3 h / Heating

9.1: 75 percent / pyridine / 12 h / 23 °C

10.1: 90 percent / KOtBu / benzene; tetrahydrofuran / 2 h / Heating

With 1H-imidazole; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; Me₂AlCl₂; potassium tert-butylate; iodine; potassium carbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol016543a