6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1428760-89-7
Molecular Formula:C₂₀H₁₇ClN₄OS₂
Molecular Weight:428.966
Hs Code.:

Synonyms:6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Property of 6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 8 articles about 6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 3581-87-1,260998-77-4
2-methylthiazole

: 1286738-66-6
6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

: 1428760-89-7
6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ISOPROPYLAMIDE; potassium acetate; at 110 ℃; for 24h; Sealed tube;

Reference yield:

: 59748-90-2
4-Bromo-2-chloro-benzoic Acid

: 1428760-89-7
6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C

2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h / -5 - 0 °C

3: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C

4: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C

5: sodium hydroxide / 4 h / Reflux

6: thionyl chloride / 1 h / Reflux

7: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C

8: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; ISOPROPYLAMIDE / 24 h / 110 °C / Sealed tube

With 4-methyl-morpholine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; ISOPROPYLAMIDE; tetrabutyl-ammonium chloride; water; potassium acetate; phosphorus tribromide; caesium carbonate; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;

Reference yield:

: 185315-48-4
(4-bromo-2-chlorophenyl)methanol

: 1428760-89-7
6-(2-chloro-4-(2-methylthiazol-5-yl)phenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C

2: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C

3: sodium hydroxide / 4 h / Reflux

4: thionyl chloride / 1 h / Reflux

5: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; ISOPROPYLAMIDE / 24 h / 110 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; ISOPROPYLAMIDE; tetrabutyl-ammonium chloride; potassium acetate; phosphorus tribromide; caesium carbonate; sodium hydroxide; In water; 1,2-dichloro-ethane;