6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1286738-66-6
Molecular Formula:C₁₆H₁₃BrClN₃OS
Molecular Weight:410.722
Hs Code.:

Synonyms:6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Suppliers and Price of 6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
6-(4-Bromo-2-chlorophenyl)-8-ethyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one 95%+
100mg
$ 340.00

Chemenu
6-(4-Bromo-2-chlorophenyl)-8-ethyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one 95%+
1g
$ 1468.00

Chemenu
6-(4-Bromo-2-chlorophenyl)-8-ethyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one 95%+
250mg
$ 787.00

AK Scientific
6-(4-Bromo-2-chlorophenyl)-8-ethyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one
100mg
$ 412.40

Total 2 raw suppliers

Chemical Property of 6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Chemical Property:

Boiling Point:526.0±50.0 °C(Predicted)
Density:1?+-.0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

6-(4-Bromo-2-chlorophenyl)-8-ethyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 10 articles about 6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1261606-45-4
(4-bromo-2-chlorophenyl)acetic acid ethyl ester

: 185040-35-1
4-ethylamino-2-methylthiopyrimidine-5-carboxaldehyde

: 1286738-66-6
6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;
DOI:10.1021/acs.jmedchem.6b00638

Reference yield:

: 59748-90-2
4-Bromo-2-chloro-benzoic Acid

: 1286738-66-6
6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C

2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h / -5 - 0 °C

3: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C

4: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C

5: sodium hydroxide / 4 h / Reflux

6: thionyl chloride / 1 h / Reflux

7: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C

With 4-methyl-morpholine; sodium tetrahydroborate; thionyl chloride; ISOPROPYLAMIDE; tetrabutyl-ammonium chloride; water; phosphorus tribromide; caesium carbonate; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;

Reference yield:

: 185315-48-4
(4-bromo-2-chlorophenyl)methanol

: 1286738-66-6
6-(4-bromo-2-chlorophenyl)-8-ethyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C

2: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C

3: sodium hydroxide / 4 h / Reflux

4: thionyl chloride / 1 h / Reflux

5: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C

With thionyl chloride; ISOPROPYLAMIDE; tetrabutyl-ammonium chloride; phosphorus tribromide; caesium carbonate; sodium hydroxide; In water; 1,2-dichloro-ethane;