1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

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Chemical Name:1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane
CAS No.:253591-18-3
Molecular Formula:C₄₃H₆₀N₄O₇S
Molecular Weight:777.038
Hs Code.:

Synonyms:1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

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Chemical Property of 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

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Technology Process of 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

There total 8 articles about 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 253591-05-8
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-propan-2-one

: 253591-18-3
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃;
DOI:10.1016/S0223-5234(00)80031-8

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 253591-18-3
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DCC; HOBT; Et₃N / dimethylformamide / 0 - 20 °C

2: 98 percent / NaOCl; sat. NaHCO₃; KBr / TEMPO / CH₂Cl₂; H₂O / 0 - 20 °C

3: 42 percent / nBuLi / 1,2-dichloro-ethane / 1 h / -25 - 20 °C

4: 98 percent / NaBH₄ / ethanol / 0 - 20 °C

With sodium hypochlorite; sodium tetrahydroborate; n-butyllithium; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Condensation / 2: Oxidation / 3: Substitution / 4: Reduction;
DOI:10.1016/S0223-5234(00)80031-8

Reference yield:

: 65838-17-7
1,3-di-(N-benzylamino)-2-hydroxypropane

: 253591-18-3
1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DCC; HOBT; Et₃N / dimethylformamide / 0 - 20 °C

2: 98 percent / NaOCl; sat. NaHCO₃; KBr / TEMPO / CH₂Cl₂; H₂O / 0 - 20 °C

3: 42 percent / nBuLi / 1,2-dichloro-ethane / 1 h / -25 - 20 °C

4: 98 percent / NaBH₄ / ethanol / 0 - 20 °C

With sodium hypochlorite; sodium tetrahydroborate; n-butyllithium; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Condensation / 2: Oxidation / 3: Substitution / 4: Reduction;
DOI:10.1016/S0223-5234(00)80031-8