65838-17-7

Basic information

• Product Name: 2-Propanol, 1,3-bis[(phenylmethyl)amino]-
• CAS NO: 65838-17-7
• Molecular Formula: C17H22N2O
• Molecular Weight: 270.374
• Mol File: 65838-17-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 1,3-bis[(phenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1,3-bis[(phenylmethyl)amino]-(65838-17-7)
• EPA Substance Registry System: 2-Propanol, 1,3-bis[(phenylmethyl)amino]-(65838-17-7)

Safety Data

• Hazardous Substances Data: 65838-17-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 616-29-5 1,3-Diamino-2-hydroxypropane 
• 100-46-9 benzylamine 
• 106-89-8 epichlorohydrin 
• 39654-32-5 N,N'-bisbenzylidene-1,3-diamino-2-propanol 

Downstream Products

• 212912-13-5 1,3-di-[N-benzyl-N-[(benzyloxy)carbonyl]amino]-2-hydroxypropane 
• 253590-69-1 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-2-hydroxypropane 
• 245679-88-3 1,3-dibenzyl-1,2,3,4,5,6-hexahydro-5-hydroxypyrimidin-2-one 
• 1010808-74-8 1,3-thiazol-5-ylmethyl benzyl(3-{benzyl-[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}-2-hydroxypropyl)carbamate 
• 212912-17-9 1,3-di-[N-benzyl-N-[((N-methyl-N-phenyl)amino)carbonyl]amino]-2-hydroxypropane 
• 126555-10-0 7,10,14,17-tetrabenzyl-15-hydroxy-1,4-dioxa-7,10,14,17-tetraazacyclononadecane 
• 126555-11-1 1,10-dibenzyl-4,7-dimethyl-12-hydroxy-1,4,7,10-tetraazacyclotridecane 
• 209522-87-2 1,4-Dibenzyl-5,7-bis-phenylsulfanyl-[1,4]diazepane-2,3,6-trione 
• 209522-91-8 1,4-Dibenzyl-[1,4]diazepane-2,3,6-trione 
• 253591-05-8 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-propan-2-one 
• 253591-18-3 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-1-phenylsulfanyl-2-hydroxypropane 
• 253590-86-2 1,3-bis[N-benzyl-N-[N-[(tert-butyloxy)carbonyl]-L-valyl]amino]-propan-2-one 
• 253590-99-7 Benzyl-(3-{benzyl-[(S)-(tetrahydro-furan-3-yl)oxycarbonyl]-amino}-2-oxo-3-phenylsulfanyl-propyl)-carbamic acid (S)-(tetrahydro-furan-3-yl) ester 
• 253591-03-6 1,3-di-[N-benzyl-N-[[(N-methyl-N-phenyl)amino]carbonyl]amino]-1-phenylsulfanyl-propan-2-one 

Relevant articles and documents

CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF

The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.

New anti-HIV derivatives: Synthesis and antiviral evaluation

A small focused library of 18 compounds incorporating the motif 1,3-(N,N'-dibenzyl)diamino-2-propanol has been synthesized, using adapted synthetic methodologies. These series of compounds were evaluated for their in vitro anti-HIV activity on infected MT4 cells (syncytium formation observation). Some of the new synthesized compounds show potent anti-HIV activities. EC50 values for compounds (31, 40, 34, 37 and 46Scheme 3(i) Na2SO4, CH2Cl2, rt; (ii) NaBH4, EtOH, 0°C; (iii) Boc2O, CH2Cl2, 0°C; (iv) DMSO, TFAA, Et3N, CH2Cl2, -60°C; (v) TFA, CH2Cl2, rt; (vi) BOP, RCOOH, Et3N, CH2Cl2, rt.) range from 0.1 to 1μM. In order to determine at which level these new derivatives interfere with the HIV replicative cycle, inhibition assays on recombinant HIV protease and HIV integrase have been performed. None of the compounds were found active on these two enzymatic targets. Experiments are in progress in order to identify their biological target within the HIV replicative cycle. Copyright (C) 2000 Elsevier Science Ltd.

Asymmetric synthesis of 1,2,3,4,5,6-hexahydro-5-hydroxypyrimidin-2-ones as potential HIV-protease inhibitors

The first asymmetric synthesis of potential cyclic urea HIV protease inhibitors of Type 2 is reported. The synthesis is short and highly versatile in the choice of the substitution pattern and absolute configuration of the products starting from readily available materials. Nonchiral central building block 5 was synthesized and subsequently asymmetrically alkylated under (R)-/(S)-1-amino-2-(methoxymethyl)pyrrolidine (RAMP/SAMP)-auxiliary control to provide 8a-e. The alkylated ketones then were reduced to the target compounds 9a-e, with good-to-excellent overall yields, as well as diastereoisomeric and enantiomeric purities.