(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

Base Information

Chemical Name:(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester
CAS No.:1055320-87-0
Molecular Formula:C₄₀H₄₃N₃O₅
Molecular Weight:645.799
Hs Code.:

(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

Synonyms:(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

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Chemical Property of (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

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Technology Process of (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

There total 10 articles about (2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 494854-35-2
3-{4-[(1-aminocyclopentanecarbonyl)amino]phenyl}acrylic acid ethyl ester

: 1055320-85-8
6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indole-9-carboxylic acid

: 1055320-87-0
(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 1055320-72-3
7-chloro-1H-indole-6-carboxylic acid

: 1055320-87-0
(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

6.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

6.2: 19 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

8.1: sodium hydride / dimethyl sulfoxide / 0.33 h / 20 - 200 °C / Microwave irradiation

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;

Reference yield:

: 1055320-74-5
7-chloro-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1055320-87-0
(2E)-3-[4-[[[1-[[(6-cyclohexyl-2,3-dihydro-5-phenyl-1,4-oxazino[2,3,4-hi]indol-9-yl)carbonyl]amino]cyclopentyl]carbonyl]amino]phenyl]-2-propenoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

1.2: 0.25 h

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

4.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

4.2: 19 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: sodium hydride / dimethyl sulfoxide / 0.33 h / 20 - 200 °C / Microwave irradiation

7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With tetrabutyl ammonium fluoride; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;