5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate

Base Information

• Chemical Name: 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate
• CAS No.: 206759-97-9
• Molecular Formula: C₂₄H₂₇NO₅
• Molecular Weight: 409.482
• Mol file: 206759-97-9.mol

Synonyms:5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate

Chemical Property of 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate

Chemical Property:

• Boiling Point: 582.5±50.0 °C(Predicted)
• Density: 1.176±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-Glu(OtBu)-H 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate

There total 8 articles about 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

γ-tert-butyl α-S-ethyl (S)-N-(fluorenylmethoxycarbonyl)thioglutamate (222639-57-8) → 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate (206759-97-9)

Guidance literature:

With triethylsilane; palladium on activated charcoal; In acetone; for 0.5h;

DOI:10.1021/jo982125g

Reference yield: 91.0%

4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-pentanoic acid tert-butyl ester (153815-59-9) → 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate (206759-97-9)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; ethyl acetate; at 80 ℃; for 2h;

DOI:10.1080/00397910701555469

Reference yield: 52.0%

Fmoc-Glu(tBu)-N(CH3)-OCH3 → 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate (206759-97-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

DOI:10.1021/ol0275567

upstream raw materials:

(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

γ-tert-butyl α-S-ethyl (S)-N-(fluorenylmethoxycarbonyl)thioglutamate

4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-pentanoic acid tert-butyl ester

Fmoc-Glu(OtBu)-OH

Downstream raw materials:

C₄₆H₇₀N₈O₈

C₇₂H₁₁₁N₁₃O₁₂

C₃₃H₃₈N₂O₆

C₃₅H₄₀N₂O₇

Refernces

• 1、 -. "PNA probe". Paragraph 0279; 0283. . Retrieved 2022/02/16.
• 2、 -. "Β?CATENIN/ B-CELL LYMPHOMA 9 PROTEIN?PROTEIN INTERACTION INHIBITING PEPTIDOMIMETICS". Paragraph 0167. . Retrieved 2020/11/03.