2-(Naphthalen-1-yl)pyrrolidine

Base Information

• Chemical Name: 2-(Naphthalen-1-yl)pyrrolidine
• CAS No.: 121193-91-7
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• Hs Code.: 2933990090
• Mol file: 121193-91-7.mol

Synonyms:2-(1-Naphthyl)pyrrolidine;

Chemical Property of 2-(Naphthalen-1-yl)pyrrolidine

Chemical Property:

• Vapor Pressure: 5.63E-05mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 346.78 °C at 760 mmHg
• Flash Point: 175.088 °C
• PSA: 12.03000
• Density: 1.078 g/cm³
• LogP: 3.59310
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

2-(Naphthalen-1-yl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1-Naphthyl)pyrrolidine is used as pharmaceutical intermediate.

Technology Process of 2-(Naphthalen-1-yl)pyrrolidine

There total 4 articles about 2-(Naphthalen-1-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

pyrrolidine (123-75-1) + naphthalen-1-yl-lithium (14474-59-0) → 2-(naphth-1-yl)pyrrolidine (121193-91-7)

Guidance literature:

pyrrolidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h;

With benzophenone; In diethyl ether; hexane; at -78 ℃; for 0.166667h;

naphthalen-1-yl-lithium; In diethyl ether; hexane; at -78 - 20 ℃; regioselective reaction;

DOI:10.1038/NCHEM.2871

Reference yield:

4-amino-4-(naphthalen-1-yl)butan-1-ol → 2-(naphth-1-yl)pyrrolidine (121193-91-7)

Guidance literature:

4-amino-4-(naphthalen-1-yl)butan-1-ol; With thionyl chloride; In 1,2-dimethoxyethane; at 0 - 25 ℃; for 3h;

With sodium hydroxide; In 1,2-dimethoxyethane; water; at 0 - 25 ℃; for 4h;

DOI:10.1016/j.tetlet.2013.06.075

Reference yield:

5-azido-2-(naphthalen-1-yl)pentanoic acid → 2-(naphth-1-yl)pyrrolidine (121193-91-7) + 9,10,11,11a-tetrahydro-7H-benzo[g]pyrrolo[2,1-a]isoindol-7-one

Guidance literature:

With trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 11h; Inert atmosphere;

DOI:10.1021/acs.joc.8b00475

upstream raw materials:

1-Cyanonaphthalene

pyrrolidine

naphthalen-1-yl-lithium