6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-1,3,5-triazine-2,4-diamine

Base Information

• Chemical Name: 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-1,3,5-triazine-2,4-diamine
• CAS No.: 1335447-56-7
• Molecular Formula: C₂₈H₃₁ClN₁₀O₃
• Molecular Weight: 591.072

Synonyms:6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-1,3,5-triazine-2,4-diamine

Chemical Property of 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-1,3,5-triazine-2,4-diamine

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Technology Process of 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-1,3,5-triazine-2,4-diamine

There total 7 articles about 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-[(7-chloroquinolin-4-yl)amino]azidopropane (1236121-98-4) + N2-(3,5-dimethoxyphenyl)-N4,N4-dimethyl-6-(prop-2-ynyloxy)-1,3,5-triazine-2,4-diamine (1335447-90-9) → 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N2-(3,5-dimethoxyphenyl)-N4,N4-dimethyl-1,3,5-triazine-2,4-diamine (1335447-56-7)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 40 ℃; for 3h;

DOI:10.1111/j.1747-0285.2011.01115.x

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N2-(3,5-dimethoxyphenyl)-N4,N4-dimethyl-1,3,5-triazine-2,4-diamine (1335447-56-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 5 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

3: tetrahydrofuran / 4 h / 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 3 h / 40 °C

With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; potassium carbonate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1111/j.1747-0285.2011.01115.x

Reference yield:

methanesulfonic acid 3-(7-chloroquinolin-4-ylamino)propyl ester (911204-30-3) → 6-((1-(3-(7-chloroquinolin-4-ylamino)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N2-(3,5-dimethoxyphenyl)-N4,N4-dimethyl-1,3,5-triazine-2,4-diamine (1335447-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 50 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 3 h / 40 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1111/j.1747-0285.2011.01115.x

upstream raw materials:

methanesulfonic acid 3-(7-chloroquinolin-4-ylamino)propyl ester

4,7-dichloroquinoline

3-[(7-chloroquinolin-4-yl)amino]azidopropane

N₂-(3,5-dimethoxyphenyl)-N₄,N₄-dimethyl-6-(prop-2-ynyloxy)-1,3,5-triazine-2,4-diamine

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