Technology Process of 1-methyl-3-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1H-pyrrolo[3,2-b]quinoline
There total 5 articles about 1-methyl-3-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1H-pyrrolo[3,2-b]quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1H-pyrrolo[3,2-b]quinolone;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.25h;
Inert atmosphere;
Schlenk technique;
methyl iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
DOI:10.1016/j.bmcl.2014.06.028
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere; Schlenk technique
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique
3.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique
With
tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; sodium hydride; trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate;
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.06.028
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere; Schlenk technique
2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere; Schlenk technique
3.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere; Schlenk technique
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique
4.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique
With
tris-(dibenzylideneacetone)dipalladium(0); diphenyl phosphoryl azide; potassium acetate; sodium hydride; triethylamine; trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate;
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.06.028
![3-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1H-pyrrolo[3,2-b]quinolone](/Databaselist/images/loading.webp)
