2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

Base Information

Chemical Name:2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol
CAS No.:166193-92-6
Molecular Formula:C₄₇H₆₀INO₄SSi₂
Molecular Weight:918.139
Hs Code.:

2-<N-(tolylsulfonyl)-N-<4-<(tert-butyldiphenylsilyl)oxy>butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

Synonyms:2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

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Chemical Property of 2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

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Technology Process of 2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

There total 7 articles about 2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 166193-89-1
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1,4-butanediol

: 166193-92-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00014a023

Reference yield:

: 130372-07-5
4-(tret-butyldiphenylsilyloxy)butan-1-ol

: 166193-92-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / triphenoxymethylphosphonium iodide / CH₂Cl₂ / -68 - 20 °C

2: 1.) KH, 2.) 18-crown-6 / 1.) THF, 2.) THF, a) RT, overnight, b) 50 deg C, 6 h

3: 87 percent / TsOH / CH₂Cl₂; methanol / Ambient temperature

4: 84 percent / I₂, Ph₃P, imidazole / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; 18-crown-6 ether; methyltriphenoxyphosphonium iodide; iodine; potassium hydride; toluene-4-sulfonic acid; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1021/jm00014a023

Reference yield:

: 149365-02-6
4-[(tert-butyldiphenylsilyl)oxy]-1-iodobutane

: 166193-92-6
2-butyl>amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-iodobutan-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, 2.) THF, a) RT, overnight, b) 50 deg C, 6 h

2: 87 percent / TsOH / CH₂Cl₂; methanol / Ambient temperature

3: 84 percent / I₂, Ph₃P, imidazole / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; 18-crown-6 ether; iodine; potassium hydride; toluene-4-sulfonic acid; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1021/jm00014a023