4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide

Base Information

• Chemical Name: 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
• CAS No.: 51626-35-8
• Molecular Formula: C₁₉H₁₆N₄OS
• Molecular Weight: 348.428
• Mol file: 51626-35-8.mol

Synonyms:4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide

Chemical Property of 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide

There total 6 articles about 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-ylthio)-N-phenylacetamide → 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide (51626-35-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.166667h; Reflux;

DOI:10.1134/S1068162015010057

Reference yield:

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) → 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide (51626-35-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol

2: acetic anhydride

3: sodium tetrahydroborate; octasulfur / ethanol / 5 h / Cooling with ice; Reflux

4: sodium ethanolate / ethanol / 0.17 h / Reflux

With octasulfur; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; acetic anhydride; In ethanol; 4: |Thorpe Reaction;

DOI:10.1134/S1068162015010057

Reference yield:

5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (51626-33-6) → 4-amino-3-methyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide (51626-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; octasulfur / ethanol / 5 h / Cooling with ice; Reflux

2: sodium ethanolate / ethanol / 0.17 h / Reflux

With octasulfur; sodium tetrahydroborate; sodium ethanolate; In ethanol; 2: |Thorpe Reaction;

DOI:10.1134/S1068162015010057

upstream raw materials:

2-mercapto-N-phenylacetamide

5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile

edaravone

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

Downstream raw materials:

8-methyl-3,6-diphenyl-3H,6H-pyrazolo[4',3':4,5]thieno[3,2-d][1,2,3]triazin-4-one

3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazol-4-ol

3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazol-4-ylamine

N-(3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazol-4-yl)-acetamide