C₂₇H₄₂O₅Si

Base Information

• Chemical Name: C₂₇H₄₂O₅Si
• CAS No.: 1357476-82-4
• Molecular Formula: C₂₇H₄₂O₅Si
• Molecular Weight: 474.713
• Mol file: 1357476-82-4.mol

Synonyms:C₂₇H₄₂O₅Si

Chemical Property of C₂₇H₄₂O₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₄₂O₅Si

There total 5 articles about C₂₇H₄₂O₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzaldehyde (1357476-71-1) + 5-Bromo-1,2,4-trimethoxy-3-isopropylbenzene (144707-40-4) → C27H42O5Si (1357476-82-4)

Guidance literature:

5-Bromo-1,2,4-trimethoxy-3-isopropylbenzene; With iodine; magnesium; In tetrahydrofuran; Inert atmosphere; Reflux;

3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1080/00397911.2010.518274

Reference yield:

methyl 3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzoate (1292688-12-0) → C27H42O5Si (1357476-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / -78 °C

2.1: dipyridinium dichromate / dichloromethane / 3 h / 20 °C

3.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

3.2: 2 h / 0 - 20 °C / Inert atmosphere

With dipyridinium dichromate; iodine; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1080/00397911.2010.518274

Reference yield:

3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzyl alcohol (1292688-03-9) → C27H42O5Si (1357476-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dipyridinium dichromate / dichloromethane / 3 h / 20 °C

2.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

2.2: 2 h / 0 - 20 °C / Inert atmosphere

With dipyridinium dichromate; iodine; magnesium; In tetrahydrofuran; dichloromethane;

DOI:10.1080/00397911.2010.518274

upstream raw materials:

methyl 3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzoate

3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzyl alcohol

3-(tert-butyldimethylsilyloxy)-2,6-dimethylbenzaldehyde

5-Bromo-1,2,4-trimethoxy-3-isopropylbenzene

Downstream raw materials:

3-hydroxy-2,6-dimethyl-4-nitrobenzaldehyde

3-(3-isopropyl-2,4,5-trimethoxybenzoyl)-2,4-dimethyl-4-(2,2,2-trifluoroethoxy)cyclohexa-2,5-dien-1-one

C₂₁H₂₆O₅

C₂₇H₄₀O₅Si