5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Base Information

Chemical Name:5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid
CAS No.:1381846-32-7
Molecular Formula:C₁₄H₁₆F₃NO₄
Molecular Weight:319.281
Hs Code.:

Synonyms:5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Suppliers and Price of 5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

There total 4 articles about 5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1381846-25-8
5-(aminomethyl)-2-(trifluoromethyl)benzoic acid

: 1381846-32-7
5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b01249

Reference yield:

: 1381846-24-7
benzyl 5-cyano-2-(trifluoromethyl)benzoate

: 1381846-32-7
5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: triethylamine / methanol / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol;
DOI:10.1021/acs.jmedchem.5b01249

Reference yield:

: 654-98-8
5-chloro-2-(trifluoromethyl)benzoic acid

: 1381846-32-7
5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 9.5 h / 95 °C / Inert atmosphere

1.2: 3.5 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: triethylamine / methanol / 2 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; triethylamine; zinc; In methanol; N,N-dimethyl acetamide;
DOI:10.1021/acs.jmedchem.5b01249