tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate
CAS No.:1381846-37-2
Molecular Formula:C₁₇H₁₉F₃N₄O₃
Molecular Weight:384.358
Hs Code.:

Synonyms:tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

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Chemical Property of tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

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Technology Process of tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

There total 6 articles about tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1381846-32-7
5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid

: 42383-61-9
2-aminoimidazolesulfate

: 1381846-37-2
tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

Guidance literature:: 5-(((tert-butoxycarbonyl)amino)methyl)-2-(trifluoromethyl)benzoicacid; 2-aminoimidazolesulfate; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1021/acs.jmedchem.5b01249

Reference yield:

: 654-98-8
5-chloro-2-(trifluoromethyl)benzoic acid

: 1381846-37-2
tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl acetamide / 9.5 h / 95 °C / Inert atmosphere

1.2: 3.5 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: triethylamine / methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C

4.2: 60 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01249

Reference yield:

: 1381846-24-7
benzyl 5-cyano-2-(trifluoromethyl)benzoate

: 1381846-37-2
tert-butyl (3-((1H-imidazol-2-yl)carbamoyl)-4-(trifluoromethyl)benzyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: triethylamine / methanol / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C

3.2: 60 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01249