(R)-N-ethanoylalanine ethyl ester

Base Information

• Chemical Name: (R)-N-ethanoylalanine ethyl ester
• CAS No.: 20918-90-5
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Mol file: 20918-90-5.mol

Synonyms:(R)-N-ethanoylalanine ethyl ester

Chemical Property of (R)-N-ethanoylalanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-ethanoylalanine ethyl ester

There total 3 articles about (R)-N-ethanoylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

DL-alanine ethyl ester hydrochloride (617-27-6) + 3-[N-(S)-2-acetoxypropanoyl-N-ethanoylamino]-2-diphenylmethylquinazolin-4(3H)-one → (R)-N-ethanoylalanine ethyl ester (20918-90-5) + 3-<(S)-2-Acetoxypropanoyl>amino-2-diphenylmethyl-3,4-dihydroquinazolin-4-one (178422-79-2) + N-[(S)-2-acetoxypropanoyl]-(R)-alanine ethyl ester + N-[(S)-2-acetoxypropanoyl]-(S)-alanine ethyl ester

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at -10 ℃; for 10h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1039/b105917n

Reference yield:

ethyl 2-acetamidopropanoate (5143-72-6) → (S)-acetamidoalanine (97-69-8) + (R)-N-ethanoylalanine ethyl ester (20918-90-5)

Guidance literature:

With Fermentative hydrolysis: Saccharomyces cerevisiae Hansen and various yeasts; In ethanol; water; at 35 ℃; for 48h; Product distribution; Fermentation cond. and enzym system involved (proteinase) investigated;

DOI:10.1016/S0040-4020(01)90011-0

Reference yield:

ethyl 2-acetamidopropanoate (5143-72-6) → (S)-acetamidoalanine (97-69-8) + (R)-2-(acetylamino)propanoic acid (19436-52-3) + (R)-N-ethanoylalanine ethyl ester (20918-90-5)

Guidance literature:

at 35 ℃; for 48h; Yield given. Yields of byproduct given; in the present of Saccharomyces cerevisiae Hansen;

DOI:10.1016/S0040-4039(00)94256-4

upstream raw materials:

ethyl 2-acetamidopropanoate

DL-alanine ethyl ester hydrochloride