6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

Base Information

Chemical Name:6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one
CAS No.:1360055-91-9
Molecular Formula:C₃₆H₄₁FN₈O₃
Molecular Weight:652.772
Hs Code.:

6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

Synonyms:6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

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Chemical Property of 6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

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Technology Process of 6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

There total 7 articles about 6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360056-56-9
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(5-(5-(4-isopropylpiperazin-1-yl)pyridin-2-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

: 1360055-91-9
6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1360055-91-9
6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 18 h / 70 °C

2: hydrogen / palladium on activated charcoal / ethanol / 18 h

3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ethyl acetate; 1,4-dioxane / 48 h / 95 - 105 °C / Inert atmosphere

4: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Inert atmosphere; Microwave

5: sodium hydroxide; water / tetrahydrofuran / 2 h / 60 °C

With potassium phosphate; water; hydrogen; caesium carbonate; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 4318-42-7
1-(1-methylethyl)piperazine

: 1360055-91-9
6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-isopropyl-piperazin-1-yl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 18 h / 70 °C

2: hydrogen / palladium on activated charcoal / ethanol / 18 h

3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ethyl acetate; 1,4-dioxane / 48 h / 95 - 105 °C / Inert atmosphere

4: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.5 h / 125 °C / Inert atmosphere; Microwave

5: sodium hydroxide; water / tetrahydrofuran / 2 h / 60 °C

With potassium phosphate; water; hydrogen; caesium carbonate; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; ethyl acetate;