2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Base Information

Chemical Name:2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide
CAS No.:1192313-69-1
Molecular Formula:C₁₈H₁₅F₄IN₄O₂
Molecular Weight:522.241
Hs Code.:

Synonyms:2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

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Chemical Property of 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

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Technology Process of 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

There total 6 articles about 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2895-21-8
2-chloro-N-isopropylacetamide

: 1192313-68-0
6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodopyrazolo[1,5-a]pyrazin-4(5H)-one

: 1192313-70-4
C₁₈H₁₅F₄IN₄O₂

: 1192313-69-1
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: 6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodopyrazolo[1,5-a]pyrazin-4(5H)-one; With sodium hydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere of N₂;

With lithium bromide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

2-chloro-N-isopropylacetamide;

Reference yield:

: C₁₃H₈F₄IN₃O₂

: 1192313-69-1
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 100 °C

2.1: acetic acid / 100 °C

3.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere of N₂

3.2: 0 - 20 °C

With sodium hydride; acetic acid; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 1192313-67-9
ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

: 1192313-69-1
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-iodo-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / 100 °C

2.1: acetic acid / 100 °C

3.1: acetic acid / 100 °C

4.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere of N₂

4.2: 0 - 20 °C

With ammonium acetate; sodium hydride; acetic acid; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;