ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

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Chemical Name:ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate
CAS No.:1192313-67-9
Molecular Formula:C₁₅H₁₁F₄IN₂O₃
Molecular Weight:470.162
Hs Code.:

Synonyms:ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

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Chemical Property of ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

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Technology Process of ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

There total 3 articles about ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 537050-14-9
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

: ethyl 3⁽⁵⁾-iodopyrazole-5⁽³⁾-carboxylate

: 1192313-67-9
ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere of N₂;

Reference yield:

: 1886994-04-2
5-amino-2H-pyrazole-3-carboxylic acid ethyl ester

: 1192313-67-9
ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diiodomethane; isopentyl nitrite / -10 - 90 °C / Inert atmosphere of N₂

2: sodium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere of N₂

With diiodomethane; sodium carbonate; isopentyl nitrite; In N,N-dimethyl-formamide;

Reference yield:

: 208173-24-4
1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanone

: 1192313-67-9
ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-iodo-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: chloroform; ethyl acetate / 6 h / Reflux

2: sodium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere of N₂

With sodium carbonate; In chloroform; ethyl acetate; N,N-dimethyl-formamide;