3-AMino-4-MethylaMinoMethylsulfonylbenzene

Base Information

• Chemical Name: 3-AMino-4-MethylaMinoMethylsulfonylbenzene
• CAS No.: 73097-51-5
• Molecular Formula: C8H12 N2 O2 S
• Molecular Weight: 200.25800
• Hs Code.: 2921590090
• Mol file: 73097-51-5.mol

Synonyms:o-Phenylenediamine,N1-methyl-4-(methylsulfonyl)- (6CI)

Chemical Property of 3-AMino-4-MethylaMinoMethylsulfonylbenzene

Chemical Property:

• Boiling Point: 434.5±45.0 °C(Predicted)
• PKA: 4.61±0.11(Predicted)
• PSA: 80.57000
• Density: 1.309±0.06 g/cm3(Predicted)
• LogP: 2.44900
• Storage Temp.: 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

N1-Methyl-4-(methylsulfonyl)benzene-1,2-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMino-4-MethylaMinoMethylsulfonylbenzene

There total 5 articles about 3-AMino-4-MethylaMinoMethylsulfonylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 4-methyl-amino-3-nitrophenyl sulfone (30388-44-4) → N-methyl-4-(methylsulfonyl)benzene-1,2-diamine (73097-51-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 3h;

DOI:10.1039/d1nj01019k

Reference yield:

1-fluoro-4-methanesulfonyl-2-nitrobenzene (453-72-5) → N-methyl-4-(methylsulfonyl)benzene-1,2-diamine (73097-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 20 °C / Sealed tube; Microwave irradiation

2: palladium on activated charcoal; hydrogen / ethanol / 2.5 h / 20 °C

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1021/acs.joc.7b01723

Reference yield:

1-chloro-4-methanesulfonyl-2-nitrobenzene (97-07-4) → N-methyl-4-(methylsulfonyl)benzene-1,2-diamine (73097-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 h / 80 °C

2: hydrogen; palladium on activated charcoal / ethanol / 3 h / 20 °C

With palladium on activated charcoal; hydrogen; In ethanol;

DOI:10.1039/d1nj01019k

upstream raw materials:

1-fluoro-4-methanesulfonyl-2-nitrobenzene

methyl 4-methyl-amino-3-nitrophenyl sulfone

4-chlorophenyl methyl sulfone

1-chloro-4-methanesulfonyl-2-nitrobenzene

Downstream raw materials:

C₂₂H₁₉Cl₂N₅O₂S