di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate

Base Information

• Chemical Name: di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate
• CAS No.: 157665-38-8
• Molecular Formula: C₂₅H₃₈ClFN₂O₈S
• Molecular Weight: 581.103

Synonyms:di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate

Chemical Property of di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate

Chemical Property:

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Technology Process of di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate

There total 2 articles about di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-36-6) → di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-39-9) + di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate (157665-38-8) + di-tert-butyl <3-fluoro-4-amino>benzoyl>-L-glutamate (157665-37-7)

Guidance literature:

With pyridine; methanesulfonyl chloride; 1.) 0 deg C, 20 min, 2.) 80 deg C, 15 min;

DOI:10.1021/jm00041a015

Reference yield: 35.0%

methanesulfonyl chloride (124-63-0) + di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-36-6) → di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-39-9) + di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate (157665-38-8) + di-tert-butyl <3-fluoro-4-amino>benzoyl>-L-glutamate (157665-37-7)

Guidance literature:

With pyridine; 1.) 0 deg C, 20 min, 2.) 80 deg C, 15 min;

DOI:10.1021/jm00041a015

Reference yield: 91.0%

di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate (157665-38-8) → (S)-2-{4-[(2-Chloro-ethyl)-(2-methanesulfonyloxy-ethyl)-amino]-3-fluoro-benzoylamino}-pentanedioic acid

Guidance literature:

With trifluoroacetic acid; for 0.666667h; Ambient temperature;

DOI:10.1021/jm00041a015

upstream raw materials:

methanesulfonyl chloride

di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate

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