(S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Base Information

Chemical Name:(S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1187028-55-2
Molecular Formula:C₂₄H₂₇N₃O₆
Molecular Weight:453.495
Hs Code.:

Synonyms:(S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of (S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of (S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

There total 6 articles about (S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₉N₃O₇

: 1187028-55-2
(S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1016/j.ejmech.2016.03.048

Reference yield:

: 499-06-9
3,5-dimethylbenzoic acid

: 1187028-55-2
(S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 18 h / Reflux

2.1: copper nitrate hemi(pentahydrate) / acetonitrile; water / 2 h / Reflux

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: 1,4-dioxane / 2 h / 100 °C

With N-Bromosuccinimide; copper nitrate hemi(pentahydrate); 2,2'-azobis(isobutyronitrile); benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2016.03.048

Reference yield:

: 550367-75-4
3-bromomethyl-5-methylbenzoic acid

: 1187028-55-2
(S)-N-(3-(2-ethyl-4-(5-(3-formyl-5-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper nitrate hemi(pentahydrate) / acetonitrile; water / 2 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: 1,4-dioxane / 2 h / 100 °C

With copper nitrate hemi(pentahydrate); benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2016.03.048